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KMID : 1011620130290050573
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Korean Journal of Food and Cookey Science
2013 Volume.29 No. 5 p.573 ~ p.580
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Physiological Activities of Leaf and Twig Extracts from Lindera obtusiloba Blume
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홍주헌:Hong Joo-Heon
저자없음:No authors listed
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Abstract
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We investigated the physiological activities of extracts fromLindera obtusiloba Blume leaf and twig (LLW: water extract fromLindera obtusiloba Blume leaf, LLE: 50% ethanol extract fromLindera obtusiloba Blume leaf, LTW: water extract fromLindera obtusiloba Blume twig, LTE: 50% ethanol extract fromLindera obtusiloba Blume twig). Total polyphenol and total flavonoid contents of LTE were 445.38 mg/g and 302.09 mg/g, respectively. The electron donating ability (95.38%) of LTE was higher than that of the LLE (93.76%), LTW (88.09%), and LLW (82.06%). The oxygen radical absorbance capacity of extracts were improved with 50% ethanol condition, rather than hot water. Superoxide radical scavenging activity and FRAP activity of the extracts were improved with an increase of treatment concentration. All the extracts (1,000 g/mL) stimulated a production of nitric oxide (NO) in macrophage RAW264.7 cells. In particular, the NO stimulating activity of LTE was μ superior to that of LLE, LTW, and LLW. The antitumor activity of LTE (500 g/mL) in A549, HeLa and SNU719 was 55.63%, 83.87% and μ 68.11%, respectively. The UVB-induced MMP-1 production in HS68 cells was suppressed by the treatment of LTE (88.28%), LLE (83.96%), LTW (80.59%) and LLW (76.08%).
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KEYWORD
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Lindera obtusiloba Blume, antioxidant activity, antitumor activity, matrix metalloproteinase-1
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